Rexford S. Ahima, MD, PhD
Year elected: 2005
Current membership category: Senior
Professor of Medicine; Bloomberg Distinguished Professor of Diabetes; Director of Division of Endocrinology, Diabetes and MetabolismJohns Hopkins University School of Medicine
1830 East Monument Street, 3rd Floor, #333
Baltimore, MD 21287
United States of America
Phone: (443) 287-4719
Facsimile: (410) 367-2042
My research is focused on the CNS and peripheral actions of adipokines. Leptin inhibits feeding, increases energy expenditure, and enhances insulin signaling by acting on arcuate hypothalamic neurons expressing NPY/AGRP or POMC. Adiponectin signals via MC4R in the hypothalamus to stimulate energy expenditure, insulin sensitivity and fat oxidation. In contrast, resistin induces hepatic inflammation and insulin resistance partly by acting on NPY-Y1R in the hypothalamus. Understanding the metabolic effects of adipokines provides important insights into the pathogenesis and potential treatment of obesity, diabetes and related diseases.
Johns Hopkins University School of Medicine (Primary)
Stuart C. Ray, MD is the representative at this institution.