Gregg L. Semenza, MD, PhD
Year elected: 1995
Current membership category: Senior
Director, Vascular Program
Johns Hopkins Univ School of Medicine
Institute for Cell Engineering
733 North Broadway, Suite 671
Baltimore, MD 21205
United States of America
Phone: 410-955-1619
Facsimile: 443-287-5618
Email: gsemenza@jhmi.edu

Honors and awards

Nobel Prize in Physiology or Medicine (2019) for their discoveries of how cells sense and adapt to oxygen availability (shared: William G. Kaelin, Jr., Peter J. Ratcliffe, Gregg L. Semenza)
Albert Lasker Basic Medical Research Award (2016) For the discovery of the pathway by which cells from humans and most animals sense and adapt to changes in oxygen availability – a process essential for survival (shared: William G. Kaelin, Jr., Peter J. Ratcliffe, Gregg L. Semenza)
ASCI | Stanley J. Korsmeyer Award (2012) For contributions to the molecular understanding of cellular oxygen sensing and cellular adaptation to hypoxia.
National Academy of Medicine (2012)
National Academy of Sciences (2008)

Biographical statement

Dr. Semenza’s laboratory discovered, cloned, and characterized hypoxia-inducible factor 1 (HIF-1), which is the founding member of a family of master regulators that direct transcriptional responses to decreased oxygen availability in virtually all metazoan species. His lab has shown that HIFs play important roles in cardiovascular disorders, cancer, COPD, diabetes, sleep apnea, transplant rejection, ocular neovascularization and hematologic disorders. Evolutionary selection of genetic variants at loci that encode HIF pathway components have been identified in Tibetan populations living at high altitude. HIF stabilizers and HIF inhibitors are currently in clinical trials for the treatment of anemia and cancer, respectively.

Institutional affiliations

Johns Hopkins University School of Medicine (Primary)
Stuart C. Ray, MD is the representative at this institution.

Specialties

Biochemistry
Cardiovascular Disease
Cell Biology
Developmental Biology
Genetics
Hematology
Metabolism
Molecular Biology
Oncology
Pediatrics
Physiology

Positions held

Professor
Laboratory Director