William E Mitch, MD
Year elected: 1981
Current membership category: Senior
Professor, Division of Nephrology
Baylor College of Med
Nephrology Division, M/S: BCM 395
One Baylor Plaza, ABBR R703
Houston, TX 77030
United States of America
Phone: 713-798-8350
Facsimile: 713-798-3510
Email: mitch@bcm.edu

Biographical statement

I am interested in the regulation of protein metabolism, especially in muscle. We have identified the mechanisms causing the loss of muscle protein that occurs in response to chronic kidney disease and other catabolic conditions. Recently, we have uncovered potential methods that could block the loss of muscle mass. These mechanisms were confirmed in cultured muscle cells and in mice that were genetically engineered to address specific questions. Our results have defined how CKD, inflammation and insulin/IGF-1 responses stimulate the ubiquitin-proteasome stystem to degrade muscle proteins.  Our goal is to develop these findings to a stage that can be tested in clinically relevant conditions.

Institutional affiliations

Baylor College of Medicine (Primary)
Wolfgang C. Winkelmayer, MD, MPH, ScD is the representative at this institution.

Specialties

Cell Biology
Internal Medicine
Metabolism
Nephrology

Positions held

Professor
Division/Section Chair