Mark A Sperling, MD
Year elected: 1980
Current membership category: Emeritus
Emeritus Professor
University of Pittsburgh
One Childrens Hospital Drive
4401 Pennn Avenue
Faculty Pavillion 8139
Pittsburgh, PA 15224
United States of America
Facsimile: 212-426-2132
Email: masp@pitt.edu

Biographical statement

We developed a Cre-LoxP model for tissue specific deletion of the Growth Hormone Receptor(GHR).We now have established cell lines of liver specific, muscle specific and fat specific GHR deletion to study phenotypic impact at the whole animal and tissue level in terms of signal transduction and glucose or fat metabolism.These models provide a unique opportunity to examine the distinct contribution of GH versus IGF-I in body, organ and tissue growth as well as to define the cellular/molecular mechanisms by which GH induces insulin resistance and contributes to diabetes mellitus and aging.

Institutional affiliations

University of Pittsburgh School of Medicine (Primary)
Alison Morris, MD, MS is the representative at this institution.

Specialties

Administration
Developmental Biology
Diabetes
Endocrinology
Metabolism
Molecular Biology
Pediatrics
Physiology

Positions held

Laboratory Director
Professor
Division/Section Chair
Department Chair, Emeritus
Section Chief