Dr. Yu brings a clinical lens to investigating the molecular and cellular mechanisms involved in immune control of viral infection. One area of investigation includes the role of dendritic cells and their immunoregulatory functions for generating and fine-tuning adaptive immune responses during viral infection. In addition, her lab centers on the analysis of immunological networks associated with immune control of viral infection using systems biology–based approaches. These studies use large-scale, unbiased techniques for generating global pictures of immune defense mechanisms against viral infection by combining high-throughput genomics, proteomics, and transcriptomics technologies with functional immunologic and virologic assays. Moreover, Dr. Yu also combines her work as a basic science immunologist with clinical and translational perspectives for improving clinical treatment options for viral infectious diseases.