Nima Mosammaparast, MD, PhD
Year elected: 2019
Current membership category: Active
Washington University School of Medicine
4940 Parkview Place
St. Louis, MO 63110
United States of America
The Mosammaparast lab is broadly interested in understanding how human cells respond to genotoxic agents, how cells differentiate between distinct forms of nucleic acid damage, and the potential translation of these studies towards improved therapeutic responses in cancer. We described the first signaling pathway that is specifically induced during alkylation damage, strongly suggeting that cells have the capacity to distinguish between different types of genotoxic modifications. Because repair of alkylation damage is critical for maintaining the genome, new insights into mechanisms that regulate alkylation repair pathways will have a broad impact on our understanding of DNA repair. Our lab uses a variety of biochemical, cell biological, and animal model systems to probe these questions. Ultimately, we hope to apply the knowledge that we gain to improve diagnostic and therapeutic outcomes for cancer.