Peter A. Nigrovic, MD
Year elected: 2018
Current membership category: Active
Dr. Peter Nigrovic is an Associate Professor of Medicine at Harvard Medical School, where he is an adult and pediatric rheumatologist at the Brigham and Women’s Hospital and at Boston Children’s Hospital. His laboratory studies basic mechanisms of inflammation, with a focus on autoimmune arthritis in children and adults. The lab has contributed to the understanding of how mast cells trigger joint inflammation; defined new mechanisms regulating neutrophil migration and monocyte development; and identified a direct role for megakaryocytes in systemic immunity and inflammation. Studies in IgG Fc glycans defined estrogen as the first in vivo modulator of IgG glycosylation, establishing a novel connection between sex and immunity. His group developed SNP-seq for experimental identification of causative non-coding variants from genome wide association study data, helping to bridge the gap between GWAS and mechanism in polygenic diseases. Clinically, his principal interest is juvenile idiopathic arthritis. He has contributed to the understanding of biological subcategories within this disease family, and his studies of its most explosive form, systemic JIA, have helped to shift the paradigm of treatment toward a biologics-first approach. In 2005, he founded the Center for Adults with Pediatric Rheumatic Illness (CAPRI) to provide for the transition and long-term care of patients with arthritis and other rheumatic diseases of childhood. He directs translational research for the 140-center pediatric rheumatology research collaborative Childhood Arthritis and Rheumatology Research Alliance (CARRA), designed and co-founded the US/Canadian pediatric rheumatology mentoring group AMIGO, leads the NIH-funded Joint Biology Consortium arthritis research infrastructure, and is co-editor of the American rheumatology journal Arthritis & Rheumatology.