Dr. de Boer is a Nephrologist, Professor of Medicine, and Adjunct Professor of Epidemiology at the University of Washington. His research focuses on the metabolic causes and consequences of chronic kidney disease. In particular, Dr. de Boer focuses on (1) the development, progression, and complications of diabetic kidney disease, and (2) the role of impaired mineral metabolism in the pathogenesis of chronic kidney disease and cardiovascular diseases. Dr. de Boer’s research utilizes a broad range of methods spanning Clinical Epidemiology, patient-oriented physiology studies, and clinical trials. Using these approaches, he has helped define the clinical course of kidney disease in types 1 and 2 diabetes, including the effects of intensive diabetes therapy on kidney disease, the evolution of diabetic kidney disease over decades in which widespread changes in clinical care occurred, and the key role played by kidney disease in the cardiovascular complications of diabetes. In addition, Dr. de Boer investigates the pathways through which endogenous and exogenous vitamin D compounds are metabolized and cleared, the impact of chronic kidney disease on vitamin D metabolism, and the effects of pharmacologic vitamin D interventions on metabolism and cardiovascular health in chronic kidney disease and in the general population. Dr. de Boer also leads clinical practice guidelines to facilitate translation of research findings to patient care.