Samir M. Parikh, MD
Year elected: 2017
Current membership category: Active
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA 02215
United States of America
Dr. Parikh is an Associate Professor of Medicine at Harvard Medical School and attending nephrologist at Beth Israel Deaconess Medical Center. Dr. Parikh received an AB magna cum laude in Chemistry from Harvard. He graduated from Vanderbilt University School of Medicine with an MD and the Founder’s Medal, thereafter completing post-graduate training at Beth Israel Deaconess Medical Center and Harvard Medical School.
His research focuses on mechanisms underlying acute organ dysfunction in the kidney and cardiovascular system. Identifying Angiopoietin-2 as a potential circulating mediator of vascular leakage and inflammation in critically ill patients, Dr. Parikh has proposed that the host vascular response to severe infections and sterile stressors may underlie cardinal disease manifestations and be both readily measurable and therapeutically targetable. The discrepancy between multi-organ dysfunction and the paucity of cell death in critical illness led the laboratory to hypothesize a role for mitochondrial dysfunction. Their studies have implicated the mitochondrial biogenesis regulator PGC1a across diverse etiologies of acute kidney injury and have identified a novel pathway linking to NAD+, the universal electron carrier. Given the role of NAD+ in aging, these results may bear implications for understanding chronic health deteriorations and the metabolic capacity to resist acute stressors.