Erica L. Herzog, MD, PhD
Year elected: 2017
Current membership category: Active
Yale School of Medicine
PO Box 208057
New Haven, CT 06520-8057
United States of America
Phone: 203.785.4181

Biographical statement

Dr. Herzog studies the mechanisms of macrophage-fibroblast crosstalk in the clinical setting of Idiopathic Pulmonary Fibrosis. Idiopathic Pulmonary Fibrosis (IPF) is an incurable disease characterized by excessive scar tissue in the adult lung. Lacking an identifiable adaptive immune component and responding poorly to immunosuppression, IPF has been considered uniquely nonimmune. Dr. Herzog was the first to demonstrate conclusively that depletion, or pharmacologic reprogramming of macrophages, opposes TGFb1 signaling in lung fibroblasts to both prevent and reverse fibrosis in animal models of IPF and in primary human cells. This process is regulated by the GPI anchored neuroimmune molecule Semaphorin 7a via the competing effects of CD29 and the transmembrane protein Plexin C1. She has shown that the CD29-mediated effects are controlled by previously unrecognized via biochemical and mechanotransductive interactions with the neuronal guidance protein Netrin-1, and that the accumulation of fibrosis promoting macrophages is opposed by Plexin C1 through a completely novel interaction with the lysosomal calcium sensing protein Synaptotagmin 7. She has also shown that aberrant activation of this pathway displays outcome predictive properties, suggesting real human impact of this work. She has a long track record of NIH funding with multiple R01 and U01 awards, and her work has been published in high impact journals such as Science and Science Translational Medicine. Most importantly, her work has contributed to the development of several drugs that are currently in Phase III trials for IPF, thereby giving new treatment options for patients with this difficult to treat and devastating disease.

Institutional affiliations

Yale School of Medicine (Primary)
Harriet Margot Kluger, MD is the representative at this institution.