MeiLan Han, MD, MS
Year elected: 2017
Current membership category: Active
University of Michigan
3916 Taubman Center
1500 E Medical Center Drive
Ann Arbor, MI 48109
United States of America
Phone: 734-615-9772

Biographical statement

Dr. Han is an Association Professor of Medicine at the University of Michigan, Division of Pulmonary and Critical Care. After graduating from the University of Washington School of Medicine, she completed her residency in Internal Medicine, Fellowship in Pulmonary and Critical Care and MS in Biostatistics at the University of Michigan. Her academic focus has been clinical research in COPD, in particular focusing on how imaging can be used to understand patient heterogeneity to define disease subtypes in COPD. She has been a key investigator in multiple NIH sponsored COPD networks including COPDGene and SPIROMICS. Working with colleagues at the University of Michigan, Dr. Han spearheaded the application of a dynamic image registration technique (Parametric Response Mapping) to thoracic CT scans in COPD. Using this technique, she demonstrated that airway abnormality even in patients without spirometric abnormality predicts disease progression. She is currently extending this work by performing histologic validation using human lung explants. Dr. Han has also recently used data from the SPIROMICS cohort to demonstrate that symptomatic smokers without airflow obstruction are at similar risk for exacerbations as symptomatic individuals with airflow obstruction. These symptomatic smokers with preserved spirometry also demonstrate large airway abnormality on CT and poorer exercise capacity than non-symptomatic smokers. This data provides the basis for an NHLBI-funded multi-center clinical trial of a dual bronchodilator in this patient population to determine whether symptoms can be improved for which Dr. Han is co-PI. Dr. Han belongs to numerous professional societies including the American Thoracic Society and the European Respiratory Society. She is an associate editor for the journal American Journal of Respiratory and Critical Care Medicine and serves on the editorial boards for Thorax and Lancet Respiratory Medicine and the Scientific Advisory Committee for the COPD Foundation and the American Lung Association.

Institutional affiliations

University of Michigan Medical School (Primary)
Elizabeth K. Speliotes, MD, PhD, MPH is the representative at this institution.