David B. Lombard, MD, PhD
Year elected: 2016
Current membership category: Active
University of Michigan Medical School
109 Zina Pitcher Place
Ann Arbor, MI 48109
United States of America
Aging is characterized by progressive functional impairment, along with increased susceptibility to diverse degenerative and neoplastic diseases. The Lombard laboratory is interested in elucidating molecular mechanisms of aging, in the hopes that new insights into aging biology may allow development of novel therapeutics to delay or prevent many age-associated diseases simultaneously. Much of our work focuses on the sirtuin proteins, lysine deacylases that extend longevity in budding yeast and other invertebrates, and promote numerous aspects of cellular, tissue, and organismal homeostasis in mammals. We are particularly interested in the sirtuin SIRT5, a protein that primarily localizes to mitochondria and regulates diverse metabolic pathways, and how SIRT5 may be involved in cancer. Other current work in our lab is focused on the complex formed by nuclear DNA and its associated proteins (chromatin) in myocardium, how this structure is damaged with aging, and potential means of reversing this age-associated deterioration. Finally, we are screening for novel small molecules that promote survival of mammalian cells in response to stressors, with the expectation that some of these compounds will represent candidate anti-aging drugs. Dr. Lombard is a tenured Associate Professor in the Department of Pathology at the University of Michigan. His work is supported by NIH, the Department of Defense, and the Glenn Foundation for Medical Research. He has received awards from the Ellison Medical Foundation, the Pardee Foundation, the America Federation for Aging Research, and the Hartwell Foundation. Dr. Lombard is also a practicing Pathologist in the area of Molecular Diagnostics.