Our research group is focused on understanding the pathogenesis of airway diseases, including cystic fibrosis and asthma. More specifically, we are investigating the role of the cystic fibrosis transmembrane conductance regulator (CFTR) in airway development, airway host defense, mucociliary transport, and smooth muscle function. Studies are being conducted both in humans with cystic fibrosis and in a porcine model of cystic fibrosis, that very closely resembles human cystic fibrosis disease. By better understanding the pathogenesis of early cystic fibrosis lung disease, novel therapeutic approaches and targets may be identified.