Dr. Shuji Ogino is the only Harvard faculty member who holds appointments in both pathology (Harvard Medical School) and epidemiology (Harvard School of Public Health; currently Associate Professor, with promotion in process). With his unique combination of expertise, Dr. Ogino established interdisciplinary science of molecular pathological epidemiology (MPE), defined as “epidemiology of molecular pathology and heterogeneity of disease.” He has been conducting MPE research with a particular focus on colorectal cancer. He has been advancing the MPE field by establishing and organizing International MPE Meeting Series, and the Second International MPE Meeting with more than 20 confirmed expert speakers will be held in Boston in December 2014. The MPE paradigm has been internationally accepted, and the use of the MPE term has become widespread. Recent highlights of his MPE research include two New England Journal of Medicine papers on colonoscopy screening and cancer molecular features (R. Nishihara et al. 2013) and the interaction of aspirin and PIK3CA mutation in colorectal cancer (X. Liao et al. 2012). In addition to the establishment of MPE, Dr. Ogino has also created novel paradigms and research frameworks, such as the GWAS-MPE approach (2011), the unique tumor principle (2012), the colorectal continuum model (2012), and the unique disease principle (2013). He has also been very active in creating the MPE Working Group and the STROBE-MPE Initiative. Because of his effort and accomplishment to establish the MPE field, Dr. Ogino received the Ramzi Cotran Young Investigator Award (2011) from United States and Canadian Academy of Pathology and the Meritorious Service Award (2012) from the Association for Molecular Pathology.