1150 West Medical Center Drive, 6520 MSRB I
Ann Arbor, MI 48109
United States of America
Dr. Speliotes is the Keith Henley Endowed Professor of Gastroenterology and Computational Medicine and Bioinformatics at the University of Michigan. She is Associate Director of the MSTP program and the Institutional Representative for ASCI at the University of Michigan where she leads effort to provide support, training and diversity efforts for the physician scientist community. She is Director of Precision Medicine for Internal Medicine where she is building biobank, analytic, and training resources to use genomic and EMR data for subtyping human diseases and matching them to specific treatments. She is an internationally known leader in the genetics of human obesity of an non alcoholic fatty liver disease. She founded and leads global consortia efforts that have identified and characterized hundreds of common genetic variants that associate with obesity, nonalcoholic fatty liver disease (NAFLD) and other metabolic diseases and traits using genome-wide association study (GWAS) meta-analysis. She has helped establish cohorts to study human disease in the US and abroad. She and her group have developed bioinformatic methods to prioritize tissues, genes and pathways highlighted from GWAS analyses. She and her group are characterizing the molecular action of NAFLD-associated variants and the genes they implicate in cellular and mouse models of obesity and NAFLD. They have created genetic marker panels to identify obesity and NAFLD subtypes and polygenic predictors of hepatic steatosis, cirrhosis and hepatocellular carcinoma. She serves on multiple national and international grant and journal review panels. Her work has earned her The Dean’s Award for Basic Science Research and multiple invited presentations at National and International Symposia. Most importantly, her work is helping to change the course of human disease to improve patient health which is her lifelong mission.
University of Michigan Medical School (Primary)
Dr. Speliotes is serving as the ASCI's Institutional Representative.