Benjamin D. Humphreys, MD, PhD
Year elected: 2013
Current membership category: Active
Dr. Humphreys is Chief of the Division of Nephrology at Washington University in St. Louis and the Joseph P. Friedman Professor of Renal Diseases in Medicine. Dr. Humphreys’ lab focuses on the cellular and molecular mechanisms of kidney injury and repair. They have developed genetic fate mapping approaches and used these to define critical progenitor cell populations in both acute and chronic kidney disease. These studies have shown that surviving epithelial cells are responsible for repair of acutely damaged nephrons. By contrast, in chronic kidney disease and fibrotic diseases of other organs, interstitial stromal cells such as pericytes and fibroblasts are the primary progenitor population for activated myofibroblasts, the scar-forming cell type. Currently the laboratory is focused on applying single cell genomics to study diseased and normal human kidney with the goal of understanding whether sub phenotypes exist among patients diagnosed with either chronic kidney disease or acute kidney injury. Dr. Humphreys received a bachelor’s degree in English and American Literature from Harvard College and an MD and PhD from Case Western Reserve University. He completed residency in Internal Medicine at Massachusetts General Hospital and a fellowship in Nephrology at Brigham and Women’s Hospital. He joined the Department of Medicine at Brigham and Women’s Hospital in 2005 and relocated to Washington University in 2015.