670 West Baltimore Street, HSF-III, Room 7106
Baltimore, MD 21201
United States of America
Dr. Charles Hong is the Director of Cardiovascular Research, Melvin Sharoky Professor of Medicine at the University of Maryland School of Medicine. Dr. Hong received his S.B. from MIT and M.D./Ph.D. in genetics from Yale University. He completed Internal Medicine residency at Yale, a cardiology fellowship at Massachusetts General Hospital, and a postdoctoral fellowship at Harvard Medical School.
Dr. Hong’s laboratory-based research is focused on chemical genetics of vertebrate development and stem cell differentiation. In a manner analogous to the classic forward mutagenesis screens, his group has conducted high-throughput chemical screens in zebrafish for small molecules that perturb embryonic patterning. His group has discovered a number of specific small molecule modulators of several key developmental pathways, including first-in-class compounds that shed new light on regulation of bone morphogenetic protein (BMP), Wnt, hedgehog, and lipid signaling pathways. Since many of these compounds function by inducing development of specific tissue types, an important goal of his research is to develop chemical probes for stem cell biology and regenerative medicine. Finally, because these developmental pathways represent important untapped therapeutic targets, the Hong group is currently exploring therapeutic potential of his small molecules in devastating diseases, including heart disease and cancers.