Dr. Anne Cappola’s research program combines population-based and mechanistic research studies to identify the hormonal underpinnings of human aging. Her work on the cardiovascular, musculoskeletal, and neurocognitive effects of subclinical thyroid dysfunction is redefining the parameters for treating thyroid disorders in older individuals. Dr. Cappola has also characterized the role of endogenous androgens in the health of older women. Her investigations in the frailty syndrome have illuminated the complex interplay among multiple hormonal axes and their evolution over time in older individuals. She has recently moved into studies of novel treatments in the frail population, investigating the role of ghrelin as the first therapeutic agent to combat unintentional weight loss in frailty.