Jonathan Scott Maltzman, MD, PhD
Year elected: 2012
Current membership category: Active
Associate Professor
Stanford University
777 Welch Rd, Suite DE
Palo Alto, CA 94040
United States of America
Phone: 650-498-8144
Email: maltzman@stanford.edu

Biographical statement

Research in the Maltzman lab focuses on memory T lymphocytes and their importance in solid organ transplantation. Memory T cells may be generated in response to infection or previous alloantigen exposure. Once generated, memory T cells persist for the lifetime of the host and provide protection from re-infection. Pre-existing memory cells are a significant barrier to successful tolerance induction and immunosuppressive strategies in solid organ transplantation. Therefore understanding fundamental aspects of memory T cell biology may lead to novel immunomodulatory therapeutics. The laboratory has developed a temporally mediated Cre-loxp deletion approach to alter signal transduction pathways in vivo in memory T cells to better understand their activation, generation and maintenance. Ongoing studies in the laboratory are designed to perturb the PI3 kinase/AKT, NF-kappaB, and RAS/MAP kinase pathways and the adaptor SLP-76 in memory T cells generated by transplantation as well as acute or chronic infection.

Institutional affiliations

Stanford University School of Medicine (Primary)
William T. Clusin, MD, PhD is the representative at this institution.

Specialties

Internal Medicine
Nephrology
Transplantation

Positions held

Investigator
Professor, Associate