Thomas P. Cappola, MD, ScM
Year elected: 2012
Current membership category: Active
University of Pennsylvania
11-113 South Pavillion
3400 Civic Center Blvd.
Philadelphia, PA 19104
United States of America
Phone: 215-662-3140
Facsimile: 215- 349-8017
Email: thomas.cappola@uphs.upenn.edu

Biographical statement

My laboratory uses the tools of clinical investigation and applied genomics to reveal mechanisms of human heart failure. This has included establishing a multicenter cohort study of advanced heart failure (Penn Heart Failure Study; PHFS) and a multicenter consortium for human myocardial transcriptomics and eQTL mapping (Myocardial Applied Genomics Network; MAGNet). Notable discoveries include the first demonstration that peripheral blood gene expression provides a clinical biomarker to track cardiac allograft rejection, identification of abnormalities in forkhead signaling and neuregulin signaling in common forms of human heart failure, and discovery of the 1p36 HSPB7/CLCNKA locus as the first bonafide genetic risk factor for non-familial heart failure.

Institutional affiliations

University of Pennsylvania Perelman School of Medicine (Primary)
Ben Z. Stanger, MD, PhD is the representative at this institution.

Specialties

Cardiovascular Medicine
Experimental Therapeutics
Genomics