Photo: Constantine A. Stratakis, MD D(med)Sci
Constantine A. Stratakis, MD D(med)Sci
Year elected: 2010
Current membership category: Senior
National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Develop
10 Center Drive, Building 10, CRC, Room 1-3330, MSC 1103
Bethesda, MD 20892-1103
United States of America
Phone: 301-496-4686
Email: stratakc@mail.nih.gov

Biographical statement

Dr. Stratakis received his medical and postdoctoral training in Athens, Greece and at the National Institute of Child Health & Human Development (NICHD), Bethesda, MD, respectively. After residency and fellowships in Pediatrics, Pediatric Endocrinology and Medical Genetics at Georgetown University, Washington, DC, he went back to NICHD, where he is Chief of the Section on Endocrinology and Genetics. In 2011, Dr. Stratakis became the Scientific Director of NICHD, NIH after serving as Fellowship Director (2002-14), Branch Chief (2005-07), Program Head (2007-09), and Deputy SD and then acting SD (2009-11). Dr. Stratakis serves currently on the editorial boards of many journals and as of January 1, 2015, is the co-Editor-in-Chief of Hormone and Metabolic Research, after completing a 5-year term as Deputy Editor of the Journal of Clinical Endocrinology & Metabolism (2010-14). Dr. Stratakis identified genes for Carney complex, bilateral adrenal hyperplasias, gigantism and other endocrine disorders. He is the author of more than 500 publications. His current work focuses on the genetic and molecular mechanisms leading to disorders that affect the adrenal, pituitary, multiple endocrine tumors and developmental abnormalities. His laboratory studies the role of the cyclic AMP/PKA signaling pathway (the PRKAR1A, PRKACA and PRKACB, PDE11A, PDE8B, and other PDEs), succinate dehydrogenase (SDHx) defects (in Carney-Stratakis syndrome, gastrointestinal stromal tumors, and related conditions), and newly described genes, such as ARMC5 (in adrenal tumors), GPR101 (in gigantism), and others. This work is complemented by transgenic mouse, fruit fly and zebrafish models for the respective genes. Genome-wide searches for a number of related genetic associations that predispose to mostly endocrine tumors and/or abnormal adrenal or pituitary development are ongoing. Dr. Stratakis' laboratory is funded by the intramural program of NICHD, NIH and by a number of smaller grants, mostly international. The laboratory has extensive collaborations with investigators, nationally and internationally (France, Belgium, Germany, UK, Italy, Greece, Israel, Brazil, Australia), and continues to train and host tens of trainees and scholars from around the US and the world.

Institutional affiliations

NIH, National Institute of Child Health and Human Development (Primary)

Specialties

Endocrinology
Genetics
Pediatrics