Warren Shlomchik, MD
Year elected: 2008
Current membership category: Senior
University of Pittsburgh School of Medicine
Biomedical Science Tower Room E1552
200 Lothrop Street
Pittsburgh, PA 15261
United States of America
Dr. Shlomchik has made or contributed substantially to three paradigm-shifting contributions to the immunology of allogeneic stem cell transplantation: 1) that recipient antigen presenting cells (APCs) are critical for inducing GVHD and their ablation by alloreactive natural killer cells (both in mice and humans) prevents it; 2) that donor APCs promote GVHD but are dispensable for graft-versus-leukemia (GVL); and 3) that memory T cells do not cause GVHD but transfer functional memory from donor to recipient. Dr. Shlomchik is testing this in the clinic along with collaborators from the Fred Hutchinson Cancer Center. These findings were published in Science (2 papers), Nature Medicine and the JCI.
University of Pittsburgh School of Medicine (Primary)
Alison Morris, MD, MS is the representative at this institution.