Robert H. Vonderheide, MD, DPhil
Year elected: 2007
Current membership category: Senior
University of Pennsylvania Perelman School of Medicine
Abramson Cancer Center
3400 Civic Center Blvd
South Pavilion Expansion, 12-114
Philadelphia, PA 19104
United States of America
Interactions of the immune system with cancer cells can either promote or suppress tumor growth and development. Dr. Vonderheide studies how this balance is regulated and under what circumstances therapeutic modulation can unleash the largely restrained power of the immune system to benefit patients with cancer. Working in both murine and human experimental systems (and a recent focus on pancreatic cancer), Dr. Vonderheide hypothesizes that successful approaches in tumor immunotherapy will circumvent immunosuppressive factors of the tumor microenvironment, repair antigen presentation and T lymphocyte function, and optimize target antigens for immune recognition. His translational work tests novel approaches such as vaccines, antibodies, gene therapy, and adoptive T cells for the treatment of cancer. He has studied 'universal' tumor antigens, and immune modulatory pathways involving CD40, GM-CSF, CTLA-4, PD-1, CD25 and CCR5.
University of Pennsylvania Perelman School of Medicine (Primary)
Ben Z. Stanger, MD, PhD is the representative at this institution.