Matthew K. Topham, MD
Year elected: 2007
Current membership category: Active
University of Utah
2000 Circle of Hope, Rm 5363
Salt Lake City, UT 84112-5550
United States of America
Phone: (801) 585-0304
Facsimile: (801) 585-6345

Biographical statement

Dr. Topham is an investigator at the Huntsman Cancer Institute and associate professor of medicine and adjunct associate professor of oncological sciences at the University of Utah School of Medicine. He studies a family of enzymes called the diacylglycerol kinases (DGKs), which are responsible for turning off the function of diacylglycerol, an important signaling lipid that is often abnormally active in cancer cells. Diacylglycerol kinases also produce another molecule called phosphatidic acid that can cause abnormal cell division leading to cancer. Thus, the diacylglycerol kinases occupy an important biological niche and their activity must be tightly regulated. This biologic mechanism is relevant to many types of cancer, but Dr. Topham has a particular interest in its relationship to lung cancer. He uses mouse models to dissect the biological function of DGKs and has discovered that they regulate numerous important cell processes important for tumorigenesis including nuclear lipid signaling, and Ras and EGFR activation. In addition, Dr. Topham’s lab studies the role of cyclooxygenase-2 (COX-2) in tumorigenesis and is specifically interested in how COX-2 and tyrosine kinases interact to promote tumorigenesis.

Institutional affiliations

University of Utah School of Medicine (Primary)
Guy A. Zimmerman, MD is the representative at this institution.


Internal Medicine