Scott B. Snapper, MD, PhD
Year elected: 2007
Current membership category: Senior
Wolpow Family Chair in IBD Treatment and Research/Director, Inflammatory Bowel Disease Center
Children's Hospital Boston/Brigham & Women's Hospital/Harvard Medical Schoo
Children's Hospital Boston
Department of Pediatric Gastroenterology
300 Longwood Avenue, Enders 676
Boston, MA 02115
United States of America
Phone: 617-919-4973
Facsimile: 617-730-00498

Biographical statement

Dr. Snapper is a physician-scientist whose research focuses on understanding the role of the immune system in maintaining health in the intestine with a concentration on inflammatory bowel diseases in very young children and human immunodeficiencies. Dr. Snapper is the Wolpow Family Chair and Director of the Center for Inflammatory Bowel Disease and Director of Basic and Translational Research at Boston Children’s Hospital. In addition, Dr. Snapper is the Director of IBD Research within the Gastroenterology Division at Brigham & Women’s Hospital (BWH) where he maintains a joint clinical appointment. He is an Associate Professor of Medicine at Harvard Medical School (HMS). Dr. Snapper's laboratory is broadly interested in cell signaling pathways that regulate blood cells and epithelial cells in health and disease. For the last decade, his laboratory has been investigating how the “adaptive” and “innate” arms of the immune system maintain health in the intestine. In particular his laboratory is trying to understand how a defective immune system can contribute simultaneously to both immunodeficiency and intestinal inflammation with some focus on humanimmunodeficiencies. Currently, his laboratory is characterizing new genes that are associated with IBD and testing novel treatment strategies to manipulate immunoregulatory circuits in mice and man for IBD disease prevention and therapy. A major goal of his recent activities is to identify the genetic, immunological, microbiological and other environmental causes that lead to very early onset inflammatory bowel disease (VEO- IBD) and to develop novel personalized therapeutic options based on these findings. Together with other colleagues, Dr. Snapper has started an international consortium ( focused on this effort.

Institutional affiliations

Harvard Medical School, Massachusetts General Hospital (Primary)
Dennis Ausiello, MD is the representative at this institution.


General Medicine