Stephen E. Kimmel, MD, MSCE
Year elected: 2007
Current membership category: Senior
Perelman School of Medicine at the University of Pennsylvania
Professor of Medicine and Epidemiology
923 Blockley Hall, 423 Guardian Drive
Philadelphia, PA 19104-6021
United States of America
Dr. Kimmel’s research has focused on determining the risks and benefits associated with coronary angioplasty and discovering cardiac effects of non-cardiac medications. He has applied the rigorous basic science of epidemiology to answer clinical questions of importance in cardiovascular medicine. His series of research studies on the cardiovascular effects of non-aspirin non-steroidal anti-inflammatory medications (NSAIDs) and cylooxygenase-2 (COX-2) inhibitors, spanning the last decade, have demonstrated that some, but not all, traditional NSAIDs may alter the risk of MI; that COX-2 inhibitors differ in their relative cardiovascular effects; and that methodological limitations of previously published, retrospective, administrative database studies could systematically bias study results. He has also identified a possibly cardioprotective effect of selective serotonin reuptake inhibitor drugs, informed by the antiplatelet properties of these drugs. In addition, Dr. Kimmel’s series of studies of angioplasty outcomes have helped to define current standards for angioplasty practice. For example, his seminal study of angioplasty laboratory volume demonstrated an independent effect of laboratory volume on angioplasty complications, and his further research confirmed these findings in modern practice but distinguished these effects from the lack of effect of laboratory volume on outcomes after discharge from the hospital.
University of Pennsylvania Perelman School of Medicine (Primary)
Ben Z. Stanger, MD, PhD is the representative at this institution.