Anupam Agarwal, MD
Year elected: 2007
Current membership category: Senior
Director, Division of Nephrology, Executive Vice Dean, UAB School of MedicineUniversity of Alabama at Birmingham
Division of Nephrology, THT 647
703 19th Street
Birmingham, AL 35233
United States of America
Phone: (205) 996 6670
Facsimile: (205) 996 6650
Dr. Agarwal is currently the Director, Division of Nephrology and the holder of the Marie S. Ingalls Endowed Chair in Nephrology Leadership in the Department of Medicine at the University of Alabama at Birmingham (UAB). He served as Interim Chairman, Department of Medicine at UAB from August 2011-August 2012 and as Interim Senior Vice President and Dean in 2013 for the UAB School of Medicine. His principal interests in clinical nephrology include acute kidney injury, specifically in the intensive care unit setting, toxic nephropathies, fluid and electrolyte disorders and diabetic kidney disease. His research efforts include three main areas. (i) His laboratory is studying the molecular regulation of the human heme oxygenase-1 (HO-1) gene in renal and vascular injury. Induction of this gene occurs as an adaptive and beneficial response to injury and is protective in several diseases including acute renal failure, transplant rejection and atherosclerosis. Studies are focused on identifying regulatory regions in the human HO-1 gene that mediate induction in response to stimuli such as heme, cytokines, nitric oxide, modified lipids and growth factors in renal and vascular injury. The studies involve molecular biology techniques to study DNA-protein interactions using chromatin structure analysis, 3C and chromatin immunoprecipitation assays. (ii) The functional significance of HO-1 gene expression is also being evaluated using both in vitro and in vivo systems in transgenic animal models of acute renal injury, transplantation, angiogenesis and atherosclerosis. His laboratory is also studying the anti-inflammatory nature of HO-1 in mediating immune responses. (iii) His laboratory is actively pursuing gene and cell therapy approaches in the kidney and the vasculature in animal models of transplantation using recombinant adeno-associated viral vectors.
University of Alabama at Birmingham School of Medicine (Primary)
Steven M. Rowe, MD, MSPH is the representative at this institution.