Philip A. Cole, MD, PhD
Year elected: 2006
Current membership category: Senior
ProfessorHarvard Medical School and Brigham and Women's Hospital
Departments of Medicine and Biological Chemistry and Molecular Pharmacology
77 Avenue Louis Pasteur
Room 168C HMS New Research Building
Boston, MA 02115
United States of America
Cole's research career has focused on the application of chemical methods to address biomedical problems. His group's scientific achievements include the development of a simple and widely used method to carry out protein semi-synthesis. In addition, his group elucidated the catalytic mechanism of protein kinase reactions, and has used this model to design protein kinase inhibitors, providing insights into the insulin receptor, Cdk, Abl, and EGFR. Cole's lab also developed the first selective melatonin rhythm enzyme, histone acetyltransferase, and histone demethylase enzyme inhibitors. Recently, his group has shown it is possible to chemically rescue a mutant enzyme in living cells.
Harvard Medical School, Brigham & Women's Hospital (Primary)
Anna Greka, MD, PhD is the representative at this institution.