Dwight A. Towler, MD, PhD
Year elected: 2004
Current membership category: Senior
J.D. and Maggie E. Wilson Distinguished Chair in Biomedical Science, Professor of Medicine
University of Texas Southwestern Medical Center
Department of Internal Medicine - Endocrine Division
5323 Harry Hines Blvd
Dallas, TX 75390-8857
United States of America
Phone: (214) - 648-2982
Facsimile: (214)-648-8917
Email: Dwight.Towler@utsouthwestern.edu
Website: http://profiles.utsouthwestern.edu/profile/156425/dwight-towler.html

Biographical statement

Tremendous unmet needs exist in musculoskeletal medicine. Osteoporosis and osteoarthritis are recognized as common and clinically important, but other serious skeletal disorders also afflict our society. In the setting of type 2 diabetes mellitus (T2DM), lower-extremity musculoskeletal disease is prevalent, costly, and exceedingly difficult to manage, with fracture, arthropathy, ischemia, ulcer, infection, and amputation commonly confronting patients and clinicians. Aortofemoral arterial calcification is a strong predictor of risk for lower extremity amputation in patients with T2DM. While not occluding the lumen, mural elastinolysis and medial calcification compromise arterial elasticity -- a material property necessary for Windkessel physiology that ensures normal tissue perfusion throughout the cardiac cycle. During aortic calcification, the Msx2-Wnt signaling cascade that controls orthotopic craniofacial bone formation is activated ectopically in the aortic valve and vessel wall. Diabetes and dyslipidemia induce expression of Msx2 in arterial myofibroblasts, upregulate aortic Wnt gene expression, and activate pro-calcific Wnt signals in aortic tunica media and valves. We have identified that paracrine Wnt/Dkk signals control arterial calcification and fibrosis in T2DM by regulating osteogenic lineage allocation of diverse vascular mesenchymal progenitors. Prosclerotic inflammatory Wnt signals initiated by TNF-alpha and IL1-beta -- but inhibited by the vascular smooth muscle  "osteotropic" receptors LRP6 and PTH1R-- mitigate the sustained activation of this arterial injury response including fibrosis.  Protein arginine methylation / demethylation has emerged as a novel target of Wnt/LRP6 regulation and a component of the prosclerotic Ddx58/RIG-I - NFAT immune signaling relay. We now study how strategies that differentially modulate skeletal vs. arterial PTH1R / Mkl1 and Wnt/Ddx58 signaling preserve cardiovascular health, and evaluate the role of PTH1R-regulated plasma extracellular vesicles as markers and mediators of cardiovascular fibrosis. 

Institutional affiliations

University of Texas Southwestern Medical Center (Primary)

Specialties

Bone
Cardiovascular Disease
Diabetes
Drug Development
Endocrinology
Internal Medicine
Metabolism
Molecular Biology

Positions held

Department Vice-Chair
Division Chief
Grant Director
Industry/Advisor
Professor
Scientific Director
Senior Investigator