David M. Koelle, MD
Year elected: 2004
Current membership category: Senior
Professor
University of Washington
UW Medicine, Room E651
UW Mailstop 358061
750 Republican Street
Seattle, WA 98109
United States of America
Phone: 206 616 1940
Facsimile: 206 616 4898
Email: viralimm@u.washington.edu
Website: https://depts.washington.edu/daid/directory/koelle.html

Biographical statement

The laboratory is interested in cellular immune responses to chronic viral infections. Viruses with large genomes, such as herpes simplex virus, are complex with regards to the identification of antigens and epitopes recognized by virus-specific CD4 and CD8 T-cells. Expression cloning techniques based on molecular libraries of viral DNA have been developed to address this complexity. Several viruses such as herpes simplex and vaccinia specifically infect skin and genital mucosa. We are studying the expression of molecules involved in T-cell trafficking to sites of infection. Clinical research in the lab includes trials and immunogenicity evaluation of candidate HSV vaccine compounds. The overall goal is to determine immunologic and other host determinants of disease severity and to contribute to the design of effective vaccines for HSV and other viral infections.

Institutional affiliations

University of Washington School of Medicine (Primary)

Specialties

Infectious Disease

Positions held

Professor, Associate