James E. Crowe, Jr., MD
Year elected: 2004
Current membership category: Senior
Honors and awards
ASCI | Stanley J. Korsmeyer Award (2017) in recognition for research leading to the development of innovative technologies for the isolation and study of antiviral antibodies and for significantly advancing the fields of virology and immunology.
National Academy of Medicine (2014)
Dr. Crowe has a large and active research group pursuing studies of human B and T cell mechanisms of adaptive immunity to viruses, and the cell biology of virus infection. The laboratory is studying an array of pathogens, including influenza, HIV, dengue virus, RSV, rotavirus, vaccinia virus, and human metapneumovirus. The work is focused on translation of basic science concepts into investigations of immune mechanisms in human subjects, especially in the context of vaccination. The research group is studying the development of immunity in humans, at a detailed level, bringing complex molecular approaches to bear on studies of immunity in the clinical research setting. Current projects are wide ranging, including molecular epidemiology of respiratory virus infection in human infants. The group is studying B cell mechanisms of adaptive immunity. The central focus of the B cell work is to determine what is the molecular and cellular basis for the poor response of human infant to viral infection or vaccination. The laboratory has recently discovered that the principal reason underlying the poor immune response of infants is the lack of somatic hypermutations in infant B cells.
Vanderbilt University School of Medicine (Primary)
Christopher S. Williams, MD, PhD is the representative at this institution.