Barry J. Goldstein, MD, PhD
Year elected: 1996
Current membership category: Senior
76 Overhill Road
Bala Cynwyd, PA 19004
United States of America
Phone: 9084871938
Email: bgoldsteinmd@gmail.com

Biographical statement

Mechanisms and regulation of insulin receptor signal transduction.Protein-tyrosine phosphatases and the regulation of hormone action.Pathophysiology of obesity and Type 2 diabetes mellitus. Dr. Goldstein is one of the leading investigators defining the role of phosphotyrosine phosphatases (PTPs) is regulation of insulin signaling and insulin resistant states. He defined the major PTPs that regulate insulin receptor and substrate phosphorylation and characterized their alterations in rodent and human disease. He showed that PTP activity is controlled by reversible thiol oxidation and defined a unique pathway whereby the enzyme Nox4 mediates an insulin-induced oxidant signal via inhibition of PTPs in insulin-sensitive cells.

Institutional affiliations

None found.

Specialties

Bone
Diabetes
Drug Development
Endocrinology
Experimental Therapeutics
Health Care Research
Metabolism
Obesity
Physiology
Translational Medicine

Positions held

Professor
Private Practice
Division Director
Editor
Investigator
Laboratory Director
Program Director
Vice President