Sumant Singh Chugh, M.D.
Year elected: 2012
Current membership category: Active
University of Alabama at Birmingham
Division of Nephrology
1900 University Blvd
Birmingham, AL 35294
United States of America
Phone: (205) 996-9641
Facsimile: (205) 996-9675
University of Alabama at Birmingham School of Medicine (Primary)
John D Mountz, MD PhD represents the Society at this institution.
Sumant Singh Chugh is Principal Investigator of the Glomerular Disease Therapeutics Laboratory. Over the past decade, his research team has investigated molecular mechanisms in nephrotic syndrome and identified several of the key determinants of proteinuria in primary glomerular diseases. Most recently, he identified the podocyte secreted glycoprotein Angiopoietin-like-4 as the major mediator of glucocorticoid-sensitive human and experimental minimal change nephrotic syndrome, and also noted defective sialylation of this protein as a major correctable defect in this disease. Based on his studies, oral supplementation with sialic acid precursors to correct defects in sialylation of Angiopoietin-like-4 is being investigated as a potential therapeutic approach for some forms of nephrotic syndrome. His laboratory has also described a major role for the Zinc Fingers and Homeoboxes family of transcriptional factors in the regulation of podocyte gene expression. Novel therapeutic strategies, that involve sequestration of these proteins outside the nucleus using concepts introduced by his laboratory, are being developed and tested. Other ongoing research efforts include a multisystem approach to integrate the different components of nephrotic syndrome, in order to better understand and treat its manifestations and complications.